- Hegade VS, Kendrick SF, Dobbins RL, Miller SR, Thompson D, Richards D, Storey J, Dukes GE, Corrigan M, Oude Elferink RP, Beuers U, Hirschfield GM, Jones DE. Effect of ileal bile acid transporter inhibitor GSK2330672 on pruritus in primary biliary cholangitis: a double-blind, randomised, placebo-controlled, crossover, phase 2a study. Lancet. 2017 Mar 18;389(10074):1114-1123. doi: 10.1016/S0140-6736(17)30319-7. Epub 2017 Feb 8.
- Hegade VS, Krawczyk M, Kremer AE, Kuczka J, Gaouar F, Kuiper EM, van Buuren HR, Lammert F, Corpechot C, Jones DE. The safety and efficacy of nasobiliary drainage in the treatment of refractory cholestatic pruritus: a multicentre European study. Aliment Pharmacol Ther. 2016 Jan;43(2):294-302. doi: 10.1111/apt.13449. Epub 2015 Nov 2.
- Hirschfield GM, Gershwin ME, Strauss R, Mayo MJ, Levy C, Zou B, Johanns J, Nnane IP, Dasgupta B, Li K, Selmi C, Marschall HU, Jones DE, Lindor K; PURIFI Study Group. Ustekinumab for patients with primary biliary cholangitis who have an inadequate response to ursodeoxycholic acid: A proof-of-concept study.
- Jopson L, Newton JL, Palmer J, Floudas A, Isaacs J, Qian J, Wilkinson J, Trenell M, Blamire A, Howel D, Jones DE. RITPBC: B-cell depleting therapy (rituximab) as a treatment for fatigue in primary biliary cirrhosis: study protocol for a randomised controlled trial. BMJ Open 2015;5:e007985 doi:10.1136/bmjopen-2015-007985
- Cordell HJ, Han Y, Mells GF, Li Y, Hirschfield GM, Greene CS, Xie G, Juran BD, Zhu D, Qian DC, Floyd JA, Morley KI, Prati D, Lleo A, Cusi D; Canadian-US PBC Consortium; Italian PBC Genetics Study Group; UK-PBC Consortium, Gershwin ME, Anderson CA, Lazaridis KN, Invernizzi P, Seldin MF, Sandford RN, Amos CI, Siminovitch KA. International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways. Nat Commun. 2015 Sep 22;6:8019. doi: 10.1038/ncomms9019.
- Trivedi PJ, Corpechot C, Pares A, Hirschfield GM. Risk Stratification in autoimmune cholestatic liver diseases: Opportunities for clinicians and trialists. Hepatology. 2015
- Carbone M, Sharp SJ, Flack S, Paximadas D, Spiess K, Adgey C, Griffiths L, Lim R, Trembling P, Williamson KD; UK-PBC Consortium, Wareham NJ, Aldersley M, Bathgate A, Burroughs AK, Heneghan MA, Neuberger JM, Thorburn D, Hirschfield GM, Cordell HJ, Alexander GJ, Jones DE, Sandford RN, Mells GF. The UK-PBC Risk Scores: Derivation and validation of a scoring system for long-term prediction of end-stage liver disease in primary biliary cirrhosis. Hepatology. 2015
- Hirschfield GM, Mason A, Luketic V, Lindor K, Gordon S, Mayo M, Kowdley KV, Vincent C, Bodhenheimer HC Jr, Pares A, Trauner M, Marschall HU, Adorini L, Sciacca C, Beecher-Jones T, Castelloe E, Bohm O, Shapiro D. Efficacy of Obeticholic Acid in Patients with Primary Biliary Cirrhosis and Inadequate Response to Ursodeoxycholic Acid. Gastroenterology. 2014
- Lammers WJ, van Buuren HR, Hirschfield GM, Janssen HL, Invernizzi P, Mason AL, Ponsioen CY, Floreani A, Copechot C, Mayo MJ, Battezzati PM, Pares A, Nevens F, Burroughs AK, Kowd;ey KV, Trivedi PJ, Kumagi T, Cheung A, Lleo A, Imam MH, Boonstra K, Cazzagon N, Franceschet I, Poupon R, Caballeria L, Pieri G, Kanwar PS, Lindor KD, Hansen BE, Global PBC Study Group. Levels of alkaline phosphatase and bilirubin are surrogate end points of outcomes of patients with primary biliary cirrhosis: an international follow-up study. Gastroenterology. 2014;147(6):1338-1349
- Griffiths L, Jones DE. Pathogenesis of primary biliary cirrhosis and its fatigue. Digestive Diseases. 2014;32(5):615-25
- Orr JG, Homer T, Ternent L, Newton J, McNeil CJ, Hudson M, Jones DE. Health related quality of life in people with advanced chronic liver disease. Journal of Hepatology. 2014;61(5):1158-65
- Lleo A, Zhang W, McDonald WH, Seeley EH, Leung PS, Coppel RL, Ansari AA, Adams DH, Afford S, Invernizzi P, Gershwin ME. Shotgun proteomics: identification of unique protein profiles of apoptotic bodies from biliary epithelial cells. Hepatology. 2014; 60(4):1314-23
- Webb GJ, Hirschfield GM. Follicles, germinal centres and immune mechanisms in primary biliary cirrhosis. Hepatology. 2014
- Brain JG, Robertson H, Thompson E, Humphreys EH, Gardner A, Booth TA, Jones DE, Afford SC, von Zglinicki T, Burt AD, Kirby JA. Biliary epithelial senescence and plasticity in acute cellular rejection. American Journal of Transplantation. 2013;13(7):1688-702
- Afford SC, Humphreys EH, Reid DT, Russell CL, Banz VM, Oo Y, Vo T, Jenne C, Adams DH, Eksteen B. Vascular cell adhesion molecule 1 expression by biliary epithelium promotes persistence of imflammation by inhibiting effector T-cell apoptosis. Hepatology. 2014;59(5):1932-43
- Dyson JK, Webb G, Hirschfield GM, Lohse A, Beuers U, Lindor K, Jones DE. Unmet clinical need in autoimmune liver diseases. Journal of Hepatology. 2014
- Griffiths L, Dyson JK, Jones DE. The new epidemiology of primary biliary cirrhosis. Seminars in Liver Disease. 2014;34(3):318-28
- Carbone M, Bufton S, Monaco A, Griffiths L, Jones DE, Neuberger JM. The effect of liver transplantation on fatigue in patients with primary biliary cirrhosis: a prospective study. Journal of Hepatology. 2013;59(3):490-4
- Pells G, Mells GF, Carbone M, Newton JL, Bathgate AJ, Burroughs AK, Heneghan MA, Neuberger JM, Day DB, Ducker SJ, UK-PBC Consortium, Sandford RN, Alexander GJ, Jones DE. The impact of liver transplantation on the phenotype of primary biliary cirrhosis patients in the UK-PBC cohort. Journal of hepatology. 2013;59(1):67-73.
- Mells GF, Pells G, Newton JL, Bathgate AJ, Burroughs AK, Heneghan MA, Neuberger JM, Day DB, Ducker SJ, Sandford RN, Alexander GJ, Jones DE, UK-PBC Consortium. Impact of primary biliary cirrhosis on perceived quality of life: the UK-PBC national study. Hepatology. 2013;58(1):273-83.
- Mells GF, Hirschfield GM. Genetics of Primary Biliary Cirrhosis. eLS. Chichester: John Wiley & Sons; 2013.
- Hirschfield GM, Gershwin ME. The Immunobiology and Pathophysiology of Primary Biliary Cirrhosis. Annu Rev Pathol-Mech. 2013;8:303-30.
- Carbone M, Mells GF, Pells G, Dawwas MF, Newton JL, Heneghan MA, Neuberger JM, Day DB, Ducker SJ, UK-PBC Consortium, Sandford RN, Alexander GJ, Jones DE. Sex and age are determinants of the clinical phenotype of primary biliary cirrhosis and response to ursodeoxycholic acid.Gastroenterology . 2013;144(3):560-9 e7; quiz e13-4.
- Carbone M, Mells GF, Alexander GJ, Westbrook RH, Heneghan MA, Sandford RN, Neuberger JM.Calcineurin inhibitors and the IL12A locus influence risk of recurrent primary biliary cirrhosis after liver transplantation. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2013;13(4):1110-1.
- Patanwala I, Walton R, Mells G, Newton J, Alexander G, Hudson M, Jones D. The Clinical Impact of Varices and a New Externally Validated Non-Invasive Inexpensive Tool to Predict Their Presence in Patients with PBC. Journal of hepatology. 2012;56:S380-S.
- Mells G, Alexander G, Jones D, Sandford R, Cordell H, UK-PBC Consortium. Pathway Analysis of the UK GWAS Dataset Implicates Key Immunoregulatory Pathways in the Pathogenesis of Primary Biliary Cirrhosis.Journal of hepatology. 2012;56:S377-S8.
- Liu JZ, Almarri MA, Gaffney DJ, Mells GF, Jostins L, Cordell HJ, Ducker SJ, Day DB, Heneghan MA, Neuberger JM, Donaldson PT, Bathgate AJ, Burroughs A, Davies MH, Jones DE, Alexander GJ, Barrett JC, Sandford RN, Anderson CA, UK-PBC Consortium, Wellcome Trust Case Control Consortium. Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis. Nature genetics. 2012;44(10):1137-41.
- Mells GF, Floyd JA, Morley KI, Cordell HJ, Franklin CS, Shin SY, Heneghan MA, Neuberger JM, Donaldson PT, Day DB, Ducker SJ, Muriithi AW, Wheater EF, Hammond CJ, Dawwas MF, UK-PBC Consortium, Wellcome Trust Case Control Consortium, Jones DE, Peltonen L, Alexander GJ, Sandford RN, Anderson CA.Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis. Nature genetics. 2011;43(4):329-32.
- Jones DE, Mells G. The genetics of primary biliary cirrhosis: the revolution moves on. Hepatology. 2011;53(1):362-4.
