The UK-PBC Risk Score Calculator uses information from the UK-PBC Research Cohort to estimate the risk (expressed in percentage) that a PBC patient established on treatment with Ursodeoxycholic acid (UDCA) will develop liver failure requiring liver transplantation within 5, 10 or 15 years from diagnosis.

The score may be used to identify high-risk patients for closer monitoring and second-line therapies, as well as low-risk patients who could potentially be followed-up in primary care.

To use the UK-PBC Risk Score Calculator, enter the laboratory test measurements and upper limits of normal (ULN) for the total bilirubin (BIL12); alanine transaminase or aspartate transaminase (TA12), and alkaline phosphatase (ALP12) after at least 12 months of UDCA, and the laboratory test measurements and lower limits of normal (LLN) for the serum albumin and platelet count in the same timeframe.

The UK-PBC Risk Score Calculator is available as a Excel Spreadsheet, which you can download on your PC/Laptop, or available as a iPhone App which can be used offline, and can be downloaded from the Apple App Store.


excel Risk Calculator MSExcel 15Kb


1. Carbone M, Sharp SJ, Flack S, Paximadas D, Spiess K, Adgey C, Griffiths L, Lim R, Trembling P, Williamson KD; UK-PBC Consortium, Wareham NJ, Aldersley M, Bathgate A, Burroughs AK, Heneghan MA, Neuberger JM, Thorburn D, Hirschfield GM, Cordell HJ, Alexander GJ, Jones DE, Sandford RN, Mells GF. The UK-PBC Risk Scores: Derivation and validation of a scoring system for long-term prediction of end-stage liver disease in primary biliary cirrhosis. Hepatology. 2015